Building a plate and PCB can get pricey if you just do one. Designing the PCB also takes some knowledge and time, but is a good skill to learn.
If you design the plate yourself, first decide what stabilisers you want to use (some are plate mounted, some are PCB mounted) and whether you want the switches to be openable while in place (allows springs / sliders to be changed and other mods to be done, but requires notches on the sides of each switch hole). There are some good threads here (on GH) with custom plates you can get ideas from. I don't recommend doing a really different, crazy layout unless you are sure it will be properly usable for you. Standard or almost standard ANSI TKL is a good one to start with. It also means your board will be compatible with most aftermarket keycap sets. ISO TKL is also okay, but there are less sets for it
You can have the plate cut by laser or waterjet for you by quite a number of places (such as this place:
http://cuttingsolutionsinc.com/ ) or simply buy a standard TKL plate or one of the custom ones made by other GHers. The only way I can see to properly DIY a plate is if you have access to a CNC machine. Some places can anodise the plate with different finishes and colours if you use aluminium (for a real custom look
). I recommend anodising aluminium plates because it makes them a little tougher and hardens the surface. Steel plates can be powder coated different colours, too. A steel plate is better if your case can flex, aluminium is fine for a more solid case or if you don't need it to be really stiff or your PCB is really solidly mounted (many mount points).
The PCB can also be produced by some online companies. With the plate, you may find it's worth doing a batch of a certain number so it uses a whole sheet of metal. Also the PCB's usually get cheaper the more you order. You may find a local electronics store that'll do a single PCB at a decent price, or you could even etch it yourself if you want to include that in your "I did it myself" portfolio of skills. A single sided board is best in that case.
You could also go "plateless", just PCB and case, although I prefer the feel of a plate mounted board and a custom really should feel special.
A handmade wooden case sounds great
Good luck and please keep us updated on your progress!