I opted for MX Red, because it was the first kind of switch I liked (still enjoy my choc mini with reds), but didn't install them, because I got some PCB-mount MX Clear switches. I wanted to give them a try and considered the PCB mount an advantage in case of that acrylic case. I loved them for typing, much more than ergo clears, thanks to the steep force/travel curve. OTOH I didn't like the pronounced bump for gaming or even controlling software (e.g., navigation in documents). That's why I'm converting my ergodox to #vintage MX Black (I might convert them to 62g Korean springs or maybe "ghost" springs from clears eventually).
I've used the keyboard to take notes in lectures (ergodox halves on my knees), write prose and code (C, Python, TeX)... and obviously control the desktop environment. My software setup of choice consists of GNU/Linux with KDE Plasma Desktop (hotkeys for nearly everything, although I like my trackballs), Firefox w/ VimFX, Vim (or Emacs w/ evil) and pandoc.
The symmetrical layout has positively affected my accuracy and typing technique in general. Speed? Not really. I usually type slower on mechanical keyboards than on scissor switches or some rubber domes, at least in bursts, but with much less fatigue.