Arrows: Fn+IJKL
Home / End: Fn+U / O
PgUp / PgDn: Fn+Y / H
Del: Fn+Backspace
Then use Shift and Ctrl with them as needed for all the shortcuts.
If you map Fn to OS/GUI/WIN position, you can do all the modifiers including Fn with the left hand while "navigating" with the right.
That's just my favourite layout, but you can move the arrow cluster to wherever you feel is best and map Home, End, PgUp and PgDn to places that make sense to you. I'm still faster on a TKL, though, since I don't have to move my hand to press Fn and think about when to press and release it. Also, habit of 20+years of using arrow and edits in their usual spots.
I found the GON software to be really good and easy to program the layouts. Pok3r will be more work to do it and still have a few more limitations.