Actually, no. It rocks. (Especially compared to trying to type one-handed from the center of a QWERTY keyboard, which I did from middle school to the end of college. That and using a cane gave me RSI, so I bitterly wish I had known about this earlier.) The Cherry switches are a lot more forgiving for me. And the shape/frequency of use layout helps immensely. I don't have to stretch or splay my hand, so my fingers don't bother me as badly, and neither does my wrist because I don't have to turn my arm to make my fingers meet the keys like I would on a flat keyboard. I just put my hand on it, and I'm on the home row. The recessed columns are good for that too.
If you're referring to the layout, it's really not that hard to get used to. For me, I hadn't been able to type anything for a year, so my fingers had pretty much forgotten the patterns they used on QWERTY anyway. One thing I did to get used to the layout was to just look at the keys and make words with my eyes, sort of like playing Boggle. Now I can touch type on it with no problem -- didn't even need the typing tutor manual.
I do have a little bit of trouble with the thumb keys sometimes because I sprained my thumb a while back, but I have workarounds. On bad days I just move over and use my index finger. Also, if my spasticity isn't too bad, I can use my left thumb to press the space, enter, and tab keys at the bottom of the numeric keypad, so that helps a little too. I also configured Open Office to do shorthand. Bless open source programmers. :-) So really, it's the best possible keyboard I could be using. It just disturbs me that this is the only ergonomic keyboard in the world made for one handed people. If Maltron goes out of business, I'm screwed.