I'm so used to hitting the "q. resply" button, typing my message, and then hitting alt+s to quickly reply.
On geekhack the "Quote message in reply?" option is unchecked by default. So I end up posting replies then going back and editing my posts to include the person answer.
At least a compromise would be to make the "Quote message in reply?" check box before instead of after the "Post Quick Reply" button when tabbing.