No, M15s really go out for that price because everyone goes crazy about it.
I think that a split keyboard can help against wrist pain, but only if it is done right. The Japanese µTRON almost does it, but it lacks mouse control and has a high pricetag. Maltron has a split keyboard with mouse support, it's just that it looks rather large and might not be suitable for programming.
The datahand is the only split keyboard to really take all those things into account. Still, it doesn't look like a conventional keyboard at all and it has a prohibitively high price. Of course, comfort probably hasn't got a price...