back on topic
i think it depends on the game you play, rowdy already mentioned that ultimately its down to your own preference, but here's some personal experience nonetheless
i used to game a lot on blues, playing mostly MOBAs, i had no problem with it because even though those games require quick burst of keystrokes, they do not require very high RPM, hence my hands are never tired from using them, but then i went on a played a REALLY spammy MMORPG and the constant RPM was very high, this lead to a lot of finger fatigue problems and lead to me switching to reds due to their lightness (i have a FC660C but its been sitting in the corner collecting dust)
so i would say, if you play a really spammy game, then you should probably consider the 45gs, but ALWAYS try out the boards before you make a purchase