I actually am dealing with this tradeoff right now. I primarily use a Cloudnine C989 keyboard (split staggered fullsize). However, I disassembled it over the weekend to de-solder the stock switches (Cherry MX Blue) and replace them with BOX Royal switches. I didn't get a chance to finish the project so I had to use a backup for work this week.
The backup is a NiZ Plum 108 standard layout. I replaced the domes with BKE redux domes (BKE Heavy in particular). While they aren't the same as stock Topre domes (I actually prefer the more snappy tactility of the BKE domes over the more rounded tactility of Topre and other clones), they still have the soft/cushion-y and smooth feel that you typically get with a dome with slider switch like Topre.
I can say without a doubt that I can't tolerate non-split boards for very long anymore. Within a few hours of use yesterday, I started getting pain in my wrists, forearms, and shoulders from using a non-split board. So I'm easily on the ERGO side of this debate. I would actually much rather use the stock C989 with the Cherry MX blue switches and suffer through all of the typos due to the light weighting/lack of tactility than use my favorite BKE Heavy switches. Although, I did try using an Ergodox EZ for about a week and developed pain in my thumbs from stretching and curling my thumbs when using the thumb clusters. So I guess the caveat is that ERGO > switch assuming you have the RIGHT ergo for you.
It's a shame because I heavily bottom out, and the soft feel of Topre/dome with slider is so nice. I had a chance to use one of the halves of the C989 that I completed the switch swap on. The BOX Royal switches are actually very similar in terms of weighting and snappy tactility as the BKE Heavy domes, although the tactility seems to slightly reduce with typing at speed with the BOX Royal switches whereas the tactility of the BKE Heavy domes stays relatively constant regardless of typing speed. The real problems are that BOX Royal switches are the harsh bottom out and the lack of "unified" and smooth key travel resulting from the contact-based metal/plastic design. I've never used o-rings, and I wonder if adding them to the BOX Royals would make them feel more "rubber dome" like. Obviously it won't help with the smoothness of the key travel though.