Would only really work a flat profile like DSA, XDA, etc, due to the extremely non-standard 2u mods. You could get away with blanks for those, but this set has the combined problems/challenges of finding keycaps that 75% already has and multiplies that with Ortho problems. It is definitely interesting, but it causes more problems than I think it solves for most people, though it may be great for yourself as a DIY one-off project.