* I think you could profitably scoot your numpad downward [right now it requires unnecessary reaching to hit 789]; personally I’d shift 0 to a thumb for the numpad, and then try to move +-*/=,. to somewhere that's as easy to press as possible, maybe on the other hand.
* On your navigation layer, up and down seem like they’re in an okay spot, but I’d move left and right up so they’re on the home row. (Maybe just swap with home/end)
* There’s no reason to put the F keys way up on the number row where you have to reach for them, if they’re going to be on their own layer. You might as well move them down to the main 3 rows of the left hand, since you aren’t otherwise using those keys.
* Are you a programmer? If so, I’d recommend moving lots of symbols away from the shifted number row, where they’re a huge pain in the ass to type fast/accurately.
* I’d recommend at least testing out having backspace on a thumb key instead of reaching 2 columns over with the forefinger. In my experience using an ergodox, having backspace on a thumb key is a really nice feature.
* * *
Overall, your layout seems pretty reasonable though. Your thumb keys are a big improvement over the ergodox I think. [Not ideal, but pretty good.]