I have actually tried this layout, among others. Besides the other issues I noted, I decided against it because it puts more work on the pinkies, and I have numbness in those fingers. Also, I type in lots of credit cards at work, so I like 3456 (amex, visa, mc, discover) on the same side. It does leave the upper row available, as well as zx and ,. instead of z and . on the ends.