I own the older black version of the MS Sculpt (the one with the external numpad). I used it daily at work until I bought a Kinesis Advantage. I think in terms of ergonomics, it sits firmly in the 'good enough' category, unless you have pretty severe issues with your hands, which doesn't seem to be the case if I read between the lines correctly. The things I didn't like about it are:
– staggered rows. If you're coming from the Freestyle, this probably won't be an issue for you; but ever since I got the Advantage, I couldn't go back to using a row-staggered keyboard for any serious amount of time
– scissor switches: I strongly prefer so-called mechanical switches now. However, I have to say that the switches in the Sculpt are MUCH nicer than those of regular office-issue rubber dome crapboards
– this is ISO-specific, but hitting that tiny left shift key is a pain! Also, while I can generally live with the ISO enter key, I often pressed the insert key by accident, as there is no gap between them and the enter key is very narrow. Both wouldn't be an issue on the ANSI version.
– the curvature of the rows makes the outer keys in the top row less reachable than they would be on a regular board
– the F-keys are horrible, but maybe not quite as horrible as the ones on my 1st gen Advantage
– while the space bar is physically split, both halves send the same key code, so there is no way to take advantage of the extra key. Missed opportunity by MS.
Apart from those issues, I really like the board and would recommend it. I'd also recommend to get the older version, as I would consider it more ergonomic (less distance to the mouse).
With all that being said – if you can afford it, the mechanical Freestyle successor is a better choice IMO.