The only time combining two cards in Crossfire or SLI makes practical sense is when you have the money to spend on two top-end cards, so you can exceed the performance of the current single top-end card, but that lead will only last some months until the new top-end card comes out, and generally is only necessary when gaming at 2560x1440 (or similar high resolutions spanning multiple monitors) and above in 2D, or gaming in 3D on polarized dual sandwich screens or alternate frame rendered gaming on 120Hz screens with shutter glasses. There is also the issue of micro-stutter which is sometimes introduced by micro-synchronization issues with Crossfire/SLI which some people can notice and are bothered by. Utilizing Crossfire/SLI also requires profiles created by ATI/NVIDIA (or the adventurous user) to kick in when certain executables are launched, and without a profile for an exe, Crossfire/SLI will not be enabled and you'll only be using one card.
Most people in most scenarios are best served by one single strong card. Less complicated, less hassle, and in many cases, more consistent performance.