Changes in layout bother me more than switch type. I go for significant periods not using my laptop, and it is heartbreaking and frustrating to have to hunt and peck. And for 2 days at Christmas, I was using the kids' netbook. (I am a big guy, and my fingers do not fit "munchkin" keyboards!) Don't even get me started on cheap-ass track pads.
Mostly I use Model M/Fs, and thus have the freedom to span the spectrum of very light clicking to ham-fisted pounding with absolutely no difference in reaction from the keyboard.
Going from finger-thrusting at something that weighs approximately the same, or more than, a 2-liter drink bottle (well, 1.75 if it is spirits in glass) instead of a 12-ounce bottle or glass, that can be a bit unsettling. One New Year's Resolution is to find dependable non-slip mats for the undersides of all boards.
Down to actual key switches, I am having more and more trouble tolerating non-tactile switches. I love click, and although I sometimes feel lost without it, a clean smooth switch that actuates high up is not bad. I must admit that I have never owned reds or clears, but I am sure that I would be at least moderately happy with them. A switch that asked me to go more than a very few mm down before clicking, engaging, giving way, or doing "something" would be extremely annoying and disorienting.
And Finally, although this is heresy, the only good thing about rubber domes is that they ask for the majority of the force at the top, so once you have started moving down, you will probably make the connection. Not enough to compensate for mush, but something.