Razer Deathadder would probably be at the top of my list for you. One of the best palm grip mice out there with a pretty flawless sensor. For most people, it works fine with no issues whatsoever. I've had my Deathadder for over a year (eventually moving to a Spawn) but during that time period, it was one of the best mice I've ever used.
Extra buttons, check. Wired, check. DPI adjustable, only 450/900/1800/3500 but I'm sure you'll find something comfortable within that range.
Seems like you're an MMO/FPS gamer, and lots of praises have been given to the DA for FPS games. What's also cool about the DA is that there is adjustable profiles for the software, so you can set up a different one for each of your applications (up to five different on-board settings). You can map all buttons to whatever you want, whether it's undo/redo in Photoshop, scroll-shooting for BF3, 1-1 binding for SWTOR, the possibilities are many.
I'm sure others will chime in shortly, but my suggestion to you would be the Deathadder.
Have fun!