PCBs increase the stability of a board compared to hand wiring. If you don't use a PCB, you need to use a plate with individual switch cutouts for your specific layout, rather than a universal layout -- otherwise switches can move around. For some layouts, that means you'll need a custom plate done anyway, and it won't be any cheaper.
Case compatibility may also be a factor. A PCB lets you build the controller into the board, whereas a hand-wired board necessitates wiring a controller, and finding space for a larger chip.
I'll be watching this thread, hopefully I can use some of these resources myself at some point! OP, please let us know what works out to be the best deal for you!