This is a tough question for me to answer, because my answer would be yes and no.
Yes, I would like a user interface that would let me do most things with the keyboard, so that I would only use a pointing device for tasks like freehand drawing.
No, I do not aspire to doing without a mouse to use Microsoft Windows, whether by virtue of memorizing the keyboard shortcuts for hundreds of programs, or by using some third-party add-in program which would supposedly allow my keyboard to take the place of a mouse.
A menu-driven interface like that on old Hewlett-Packard terminals, where the keyboard had eight function keys and the screen showed what they did at the current time, would have the potential of taking a load off the mouse if it were made an integral part of Windows, and if you actually could use it to navigate deeply into the menus of the applications you used.
But something like that which I would have to set up myself for my favorite applications would not be worth the trouble, and so no solution to this problem would be of much value unless it were "the standard". This is a pity, since it makes it tougher for genuine innovations, like the forthcoming Eee Keyboard (their PC in a keyboard with an integrated touchpad) to gain a foothold - essentially, only Microsoft is free to innovate.