So the answer is: the layout isn't a problem.
I just tried to get these blue numpad keys on my dell laptop to work like that with the function key and couldn't. Seems like a pain. (but that was literally my first attempt, I've never done that before. its also my only non fullsize keyboard)
That kinda sucks that there isn't a switch on the bottom to make it not do that and act normal or something. Though that might be technically not possible because it may be physically multiple keyboards on the inside to deal with matrix stuff, unless it only happens in the controller and it has the usual setup for PS/2 connections so I'll stop speculating.
What does that actually do to OS X with it acting like that? I know I can literally plug in a PS/2 board and then a bunch of USB keyboards and type on any of them at any time in windows, so I don't know why that's a problem.