Personally it's a scissor for me in terms of typing all day, although some of the other guys I work with like the Topres enough... but generally speaking, there's been enough apathy and also 'it's uncomfortable' complaints about the Filcos and Topres to start me thinking that I might have thrown several thou down the plughole.
Even in terms of the stuff I bought for personal use at home, I'm also going though a bunch of mice recently so I was thinking my wrist pain was a result of having to acclimatise to several mice, but it didn't explain the other hand - so I decided as a control to switch back to alternating between the Logitech Illuminated and Sidewinder X6. Wrist pain went away in just over a day from using the Topre as my primary keyboard.
So while the nerds here get over-involved with keyswitches, as shrap correctly alludes to it's how well the entire keyboard works for you. Ergonomically none of the generally available mechanicals are anything special. If a regular keyboard is going to cause you issues, it's just as likely to cause issues while using a Filco, Deck, Topre, etc.