I had a problem a few years ago with hitting Insert by mistake way too often, and it was driving me mad. Being a dome board, I just pulled the dome and replaced the keycap. Sorted. These days I find myself using that key quite a lot anyway.
I sometimes hit LWin by mistake, but since I use that key extensively, there's no use in blocking it.
Besides, now I know about AutoHotkey, I can just convert any key into a no-op.
Keys that are good candidates for blocking (or violent and humiliating abuse) are things like Power Off where Page Up is supposed to be. Thank frak that, on keyboard with said layout, the power keys didn't work. (Nor did half the Display control panel for that matter.)