Here's the layout I'm planning to use with this board. As mentioned before, it was inspired by the Humble Hacker layout. The main ideas are:
1. Stay close to standard keyboard layouts.
2. Keep the hands as far apart as possible, so that wrists won't have to tilt inward so much. This is in consideration of the unstaggered keys. Straight wrists will hopefully make it easier to reach fingers in purely vertical motions. Similar to Kinesis keyboards.
3. Be accommodating to Emacs and Vi users. Control, Alt, Escape, and : are easy to reach.
Of course this is all just speculative until I actually try it on the board.