I was curious if there's such thing, and if there isn't if there's some reason that I'm missing as to why it couldn't/shouldn't be done. To give you an idea of what I'm talking about, I made this amazing (tm) picture in paint:
Here the wrist and arm are horizontal and the natural curve of the fingers falls inwards into a groove where the trackball sits. The main buttons are operated by the thumb, the opposite site is up for debate depending on whether you want to make it ambidextrous or right-handed only.
Though I've illustrated it with a scroll wheel for the thumb, I'd prefer it even more using the Kensington Slimblade's twist-to-scroll feature.
Edit: 1000th post, woohoo!