If you're a palm gripper, I can't help you but if you prefer claw or fingertip grip, then IMHO non-profiled (somebody should get a Nobel's prize in marketing for the term "ambidextrous" in this context) mice are better. I swapped hands as a kid (I started off being left-handed, they made me switch because apparently I wasn't being consequent enough to be left alone; what remained for a time was the ability to use the left hand for certain sorta-precise purposes) and it worked great on an old-style not so tall non-profiled mouse. I think I prefer non-profiled mice anyway, regardless which hand.