This is maybe semi-related, but back in my rubber dome days, I used to alternate between two different ANSI layouts - one with a 2.25x Enter, a 1.5 \| above it, and a 2x Backspace above that, and one with an ISO-like Enter, a 1x backspace, and a 1x \| to the immediate left of the Backspace.
I think more keyboards were for former layout (what AFAIK now is standard ANSI layout), and I found that I preferred that.
But switching between them was difficult, not because of the different Enter key size, but because the different Backspace key size and the different \| key position (under DOS, used to separate path components).