What are your issues with the layout? The layout can be changed up fairly easily.
The main issue was that I don't get F11 or F12 keys, but the split backspace and unstandard bottom row also didn't bode well for me.
I plan to do the mod to totally fix my bottom row, along with Backspace and Enter, but it is not a trivial undertaking.
About function keys, I always set the left F10 to "Windows" since I never use F10 anyway. I do use F11, often, and would probably reset F9 to F11 if I did not have upper function keys.
What does F12 do, anyway?