This has come up before. There are several threads where this has been discussed already.
Anyway.. A regular plate for Cherry MX switches is 1.5 mm thick. It can't be thicker than ~1.6 mm or so if the switches are going to snap to the plate. A single sheet of acrylic in that thickness would be too brittle for direct wiring, but it could hold up if you have a PCB.
If you go acrylic, then there are two options:
- Use 1.5 mm thick acrylic but make sure that it is very well supported. You could have a second plate with larger switch holes glued to the underside of the plate, but then it would not no longer be transparent and you would probably want to paint it before mounting the switches.
- Use a thicker sheet of acrylic for the plate: up to 5 mm. Then the switches would not snap to the plate - only be force-fitted to it. You would have to glue them in ... or of course, use a PCB.