Nothing like jumping in the deep end - this certainly qualifies
I'm quite intrigued as to what keymap you're planning that utilises big keys in the corners, but other than that the only thing that looks like it could be an issue is the keys top middle and the top stabilised one in the middle which look dangerously close on the top corners. Probably workable with custom caps though...
It looks like you've drawn this plate yourself (very impressive!) but if you're worried about the stabs you could try making the layout
here and running it through Swill's plate designer to get a plate that will work. Are you planning to get the plate cut or 3D print that too?