I could for some reason never get into American comics. Growing up, I had a fondness for Uncle Scrooge, not Superman.
More recently, I bought a few of the big volumes of The Darkness and got turned off in the middle when it had a note indicating "this subplot continues in *some other series*." I keep trying to convince myself to try Deadpool, but I'm not even sure where to break into a lot of these long-running series-- there's either no clear "This is No. 1 of this storyline" or there is and it costs as much as a G80-5000 because it's collectible.
Right now, I do follow three manga series-- One Piece, Dance In the Vampire Bund, and Monster Musume. Make of that what you will.