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I have a QFR and a QFS, and I've had all sorts of keycaps on there, including SA and DSA (both of which are spherical).
QFR has Costar stabilisers which includes little plastic clips inserted into the underneath of the larger modifier keys and then hooked over a short metal bar on the PCB. This arrangement is very tolerant of slight irregularities in keycap manufactuer.
What switches have you got?
If they are lighter switches e.g. MX blue/red/brown, then I'd say SA profile keycaps would be too heavy. There's a lot of plastic in those keycaps.
DSA, however, would be fine on any switch.