Does anyone know of an LED driver that allows the use of an input signal (HDD LED wires) for controlling a batch of LEDs?
I can't answer definitively, but I don't think there would be anything that would work that way directly. I'm sure, however, that you could use the HDD LED signal as an input to a microcontroller, then drive the LEDs from that point...
Yeah I am only planning on running 2 LED's from that so I would think the motherboard would be able to give out 40mW ish to drive a pair of LED's. Though having a full backlit board as HDD activity LED would be interesting. I suppose I could plug a pair of LEDs in parallel to the power indicator pins on the motherboard. I would assume that they have the same output characteristics.
HDD Activity backlit keyboard... I think the idea just gave me an epileptic seizure

You can probably just run the two LEDs in parallel directly from the mobo, or if you want it a little safer/more complicated, use the HDD LED signal to operate something like this
optocoupler Wire up the HDD activity LED to the A (1) & C (2) pins, which in turn drives the 5 & 4 pins - run power from the 5v or 12v rail from the PS into pin 5, and the Anode of your LED group to pin E... then the LED cathodes back to ground on the same power rail.