Honestly, I could see plenty of stuff done as scancode macros.
I handcode a lot of HTML in my job, so I could see a lot of use in, say,
Control-X
Shift-Insert
I like the media keys as an option so I don't have to find the media player and send it keystrokes. I tried using a Media Centre remote which came with my TV card, but there's no tactility, and the wirelessness sucks too.