Check out Silent PC Review.
1) Aluminum cases are the worst for noise even though they look pretty and are lightweight. There are some cases designed specifically to reduce noise (Antec has a ton of great cases, for instance). Panels that are laminated (metal/plastic/metal) really dampen sound much better than just plastic, steel or aluminum.
2) Most people have huge overkill on their power supply. Measure how much power your computer uses under full load. Most people use less than 300 watts, so it makes no sense to have a 1000 watt power supply, even in an SLI system. You definitely want some headroom to keep your power supply in its most efficient range, but more than double is way overkill.
3) Bigger fans move more air at lower RPM and are radically quieter. The worst noise sources tend to be those tiny chipset fans and video card fans, or cheap stock processor coolers. Get a fanless motherboard to eliminate that noisemaker completely. Get over-sized after-market heat-sinks with 120mm fans for your processor and video card. You can get better cooling and less noise.
4) 10,000 RPM hard drives are huge noisemakers. Better to get an SSD plus a quiet 7200 RPM drive, or even a 5400 RPM power-saving drive if you are obsessive about noise. Use silicone grommet things to mount hard drives and fans so vibrations are dampened before they're transferred to the case. You can even mount your hard drives with bungees if you're really serious.
5) Get a fan controller and use temperature monitoring software with your machine under load to optimize your fan speeds to keep your noise levels at a minimum while keeping things safely cool.
Thank you for the insight, and I'll definitely browse the link.
However, just a few things in response to the list:
1) Totally understandable, which is why I mentioned that I have an aluminum case in the OP. But at this point, nothing I can really do about the case I bought...unless they have fancy 3rd party panels that I could replace or something.
2) My PSU is 750w (powering core i5-750, 8GB RAM, 7200 RPM HDD, DVD-RW, GTX 560, Hyper 212 CPU fan and 3x Case fans) and under load prior to adding the graphics card, didn't make any substantial noise. The current noise I'm experiencing is certainly coming from graphics card.
3) Of the 3 case fans I have inside, 2x are 120mm, with the top blowhole being 80mm. All are low noise fans, under ~23 db. I think the 80mm one is like 12-15 db.
4) My plan is to get an SSD eventually. Currently I'm using a low db 7200 RPM drive. I'm not particularly obsessive about the noise, I'm just looking to make this setup a little quieter.
5) I think this option is something I need to start looking into.