Yes, and there is nothing you could do about some of the differences. But couldn't keycap swapping and a tweaked keymap bridge most of the difference?
Obviously he can made an ANSI UK board with a key less, but when one is used to an ISO board the logical layout is a minor thing, the difference between US and UK are not so huge.
What one misses more is the phisical layout, the ISO enter, and so on... This is obviously limited to the UK layout, other national layouts are way more different than US and also the logical layout is more important than the phisical one.
Anyway I made the
UK-ANSI layout, meant to use the ANSI boards with the UK-extended logical layout behavior and with easy access to the £ and € signs.
In that case no key swapping is involved.