Personally I didn't like moving the right hand so much when reaching for Backspace, so Colemak's Backspace on Caps Lock was a very welcome addition. I'd recommend it to anyone, regardless of other layout choice.
On the
TrulyErgonomic I had Ctrl right to the left of the A key (the normal Caps Lock position), and it was quite nice to have a Ctrl key close to the home row too. Note as a Mac user the Ctrl key isn't used all that often though; the main Mac modifier is Command, which got the highly coveted left thumb spot. It wasn't necessary to move Backspace because it was already somewhere close.
Nowadays (using a
Kinesis Advantage) I have both Backspace and Enter almost right under my thumbs, which feels great.
Anyway, on a standard keyboard I felt that the reach for the original Backspace key was much worse than the reach for the Enter key, so I preferred getting Backspace closer to the home row. But whatever floats your boat.