I cut my sheet of PMMA (plexiglass is just too ambiguous) with a hacksaw. It was very easy, and worked out great. You can also score it a lot, though I would say this is a better solution for PC (Lexan), or more brittle clear polymers.
Scoring through the PMMA with a knife was surprisingly easy, you could cut through the entire thing that way, and it's an easy way to make a beveled edge, if yo think you need one.
I made an amp case out of it, and drilled the holes with a normal saw (a battery saw hooked up to my benchtop PSU because the battery is dead. I "slowed it down" to 9/10 the normal voltage or so.) and I finished the odd-shaped IEC inlet with a sharp knife. For the drilling, I started small, and slowly worked my way up to the size I needed. It was easier than I thought.