It might sound weird, but I got my first TKL keyboard today (CM QRF MX blacks).
I tend to judge the distance to the arrow keys from where the number pad is, so it's still kinda throwing me out.
But my mouse is closer on the right, and it feels as if the entire keyboard is right in front of me, and the mouse just here too. Surprisingly, after only about an hour, I already really like this setup.