Like the people who claim to use the Home button they use it once and feel like it belongs on a keyboard.
I and many, many others use the Home and End keys hundreds of times a day. ![Tongue :P](https://cdn.geekhack.org/Smileys/solosmileys/tongue.gif)
Yeah. Home and End aren't particularly unusual. The only really unusual key these days is scroll lock. Pause/Break sees regular use despite being "obsoleted" because it's the abort sequence for a lot of things. (VS2010, for example - I forget if it's build abort or enter breakpoint or both.) But even Scroll Lock gets used a lot - FreeBSD uses it for console scroll control, as an example. That's one of the reasons for more keys rather than less, really. Numpad is arguably extraneous (you can do without it easily enough; it's duplicated keys essentially) but it's not like people want to hit Ctrl+Shift+Esc+F12. Hell, most people can't. So, you got Windows keys.
As things got more powerful, enabling more multitasking, 101 became too few. Leading to 105. Which has now become too few again. I say we just beat on Microsoft and Unicomp till we standardize on 24 F-keys with a standard modifier template for media keys (they do have specific scancodes.)
![Tongue :P](https://cdn.geekhack.org/Smileys/solosmileys/tongue.gif)