And there were conceptual differences - before the electric typewriter (yes, I learned on a manual in the late 1960s) "carriage return" was a foot-long sweeping motion with your right hand several inches above the keyboard that did not rate a key at all.
There were no Controls, Alts, or Escapes, among others. The Backslash/Pipe certainly has no reason to be more than 1x, but I think that the large Backspace was a stroke of genius (pun intended). Tabs were more important then than now, since there were no spreadsheets.
I always figured that the Caps Lock and Backslash ended up as they did to mirror Tab and Enter, to balance the board. Caps Lock on a typewriter had to be beside Shift for mechanical reasons.
Control and Alt got relegated to the bottom, out of the way, because they were perceived to be "lesser-used" and odd at the time.
These are my thoughts, anyway.