How are you going to F10+N if you dont have Fkeys...
Options -> Hotkeys -> Global -> Menu -> Change "Main Menu" to something other than F10
I wouldn't agree about the switches, as blacks are very tiring. Also, depending on how high level you are, you may need the F1 or F2 keys for idle workers and your army, usually for lower league players. Numpad is only really used for spectating in games.
With the exception of certain behaviors of shift and control, you can change anything you want to with the hotkeys (ignoring arcade games). That's why I recommend just getting a smaller keyboard so that the mouse arm can be in a comfortable position. That's all that really matters imo.
A lot of really good pros use blacks. It may be "better" to have lighter switches, but it is mostly a personal preference thing.