Some affirm they don’t use the arrow keys much, for myself I use them more frequent than any other key. So it’s probably a matter of typing habits. It makes no sense argueing ideologically, since we all have different typing habits. Better create a layout concept on the basis of personal questions:
1) which keys do you personally use how often? which do you use the most? (key usage frequency)
2) which keys are in best reach for your fingers. (key accessability)
then assign those keys you are using most frequent to the keys which are in best reach. If you get rid of keys you don’t use at all (e.g. CapsLock, ScrollLock, RightShift, Pause, WinKey, AppKey), then 60% keyboards have enough keys to allow every function you need.
For me, Home, End, PageUp, PageDown are completely unnecessary as standalone keys, because I feel more comfortable to access those functions by combinations with Fn and arrow keys. I don’t like Ctrl+Left, ..+Right, ..+Up, ..+Down for Home, End, PageUp, PageDown, since those key combinations are already in use for jumping from one cluster of characters to the next cluster. I prefer Fn (Fn+Left, ..+Right, ..+Up, ..+Down) to do that.