Are there skype binaries for 64bit kernels? I think this is another thing that were holding people back for a while. On a single machine, find one that works and does what you need. When you ahve more machines, you want to minimize variations so that you dont have to keep track of a million bugs and work arounds. For me this means 64 bit debian on servers and 32bit ubuntu on workstations.
Plus, I use current -1 ubuntu versions (so now 8.04) unless I really need something in the new version that isn't in backports and that I really for some reason don't want to compile from sources. The reason is that I don't like reporting and solving bugs anymore, I just want to use a computer.
Also, if you have only 4GB of memory, you actually gain very little usable memory over 32 bit due to how the memory is addressed, IIRC. Get up to 8 or 16gb and it becomes a real issue, but at 4, who cares. These days, even with 100 firefox windows open, unless you are gimp-ing and cinerrella-ing left and right you won't use over 2gb anyway.
Last note, I completely agree with iMav's recommendation to start in a VM environment. That way you can instantly switch to OSX if you need to work, and can play with ubuntu anytime. Unless you are a programmer or other type of developer or have someone who can help you, I'm not sure how much sense it makes to move away from OSX, which is already an excellent OS for mainstream use. Of course its cool to learn to use it and some of the things that prove best for use in the long run dont seem to make sense at first.
Also, such benchmards as zlib compression or MD5 hashing are USELESS in the real world unless you do these things all day. You are waiting for Open Office to load from a disk or the next geekhack forum page to load from internet. How often do you create multi-gig compressed files? Uhm, never? So in the real world there is NO, I repeat NO difference in user performance between 64 and 32 bit os unless you are running a server sending out hundreds of pages a second or running nonstop database queries. And even then, adding an extra disk to your RAID5 array will likely make a bigger performance impact. Pshew, had to get that off my chest.