On the "standard" layout, staggering among rows is inconsistent, i.e. the number row is shifted more to the right (or less to the left, if you like) than every other row of alphas. I always had trouble with it... until I discovered *THE ERGODOX*! (Okay, any symmetric matrix/columnar layout should work.) Then, it's only a tiny issue to learn symbols on the number row by heart.
I don't mind blanks, but they're counter productive, whenever I need to type something like a password on US QWERTY (a layout I don't use) to access an encrypted hard drive or something like that. In those situations, at least a colorful keycap set is helpful.