I don't think it's any different/more unusual than the next thing. Practice. I used a typing trainer just to get familiar with Kinesis Advantage and Colemak at the same time (several times a day for several weeks, but chose to go organic once the motions were comfortable and layout was learned.
The only other consideration is comfort, pain, ergo concerns. I'm banking that 95% of people that say Kinesis Advantage is causing pain are in fact not positioning correctly.