Since I got my first Windows 95-based PC in 1997, I ran anti-virus software - ThunderBYTE Anti-Virus (TBAV). It worked well and was unintrusive, and never noticeably slowed my PC.
My next PC, in 2000, ran Windows 98SE and came bundled with McAfee VirusScan 4.0. To begin with, this also worked great, the DAT updates never caused problems. There was a bit of slowdown, but nothing too bad. Then came the engine update and I came close to throwing that PC down the stairs. McAfee turned a brand new Pentium III PC into something that performed worse than the P133 it replaced. The whole system would freeze for several seconds when doing certain tasks (open a folder with a zip file - bang, freeze). It never locked up and had to be reset, it was just continual pauses.
I was offered a free update to McAfee VirusScan 5.0, and I downloaded it. Since this used the same engine as the updated v4.0, it performed just as bad, but also suffered from several new bugs and caused various blue screens of death.
Not long after that I updated to Windows XP. VirusScan 5.0 on XP was equally as appalling. It no longer caused the cursor freezes, but the system was still unresponsive and generally unstable. Insert an Iomega Zip disc into the drive - BSOD. I gave up after several weeks of battling with that god-awful software.
I went with Norton AV2002, and it made a refreshing change from McAfee (or McCrappy as we called it). But after 2002, Norton began to go downhill and became a resource-hog like McAfee. That's a lie, it was like McAfee back in 2001 - from v7.0 onwards McAfee became such bloated crapware that I think anybody would struggle to match them in its crappyness (which was a shame because VirusScan Enterprise 8.0 was a reasonable product). Nobody wants their PC to be hijacked, but then nobody wants their PC to perform like crap and be crash-happy either.
Since 2004 I've run without anti-virus software, and touch-wood I've not had a single virus infection. But as careful as you are, you never know if somebody is going to come and "check their PowerPoint presentation" on your PC and plug in their virus-infected USB memory stick. So I've been trying various anti-virus packages (freeware and various trials) and so far I'm really liking the Norton 2009 range. I've got the trial of Norton Internet Security 2009 installed, and it's fantastic. I can't notice any system slowdown that can be attributed to Norton, no annoying nag screens, no weird firewall glitches. It just works. I'll keep it installed until the trial runs out, but I think I'll probably end up buying this one. None of the free antivirus packages gave such a good impression, and Norton isn't expensive if you're installing on 3 family PCs.
So for now, this is a thumbs up for NAV2009/NIS2009.