Well, while using nearly only german layouts with ä, ö, ü and some other changes, I have a Lycosa US-layout. Ok. The missing keys mentioned above is a problem, despite not being used very often. But overall, I like the ANSI-Layout more... with some changes because of my personal taste.
I think, most of the people would start whining if there would come some changes (in fact it is a social problem of many people... whoa... changes... not before I die^^).
This Forum has lots of skilled writers but look out of the window.
Most of my collegues aren't able to write properly even though they work with their Keyboards every day.
Then there are those casual writers who only write a few words for ebay or facebook.^^
Changing things which everyone know well is always a problem of flexibility of the people.
I think, I wouldn't miss Caps-Lock. The opposite: I really hate this key.
Scroll Lock is useful for Teamspeak push to talk. xD
For work, since I am a technical draftsman, i would like to have a backspacekey like on the G80-3700 or the G84-4700. I really like the idea of using a keyboard without a Num-Cluster and combine it with some of these Keypads instead.