Very welcome Frog! And I'm super glad if I could add anything that ends up being helpful! =)
I have some experience with making one piece silicone molds for fine, detailed concrete casts and I never used something as advanced as a vac chamber, but always wished I had access to one...
So I can only estimate very roughly what it might be like, but I think getting rid of bubbles as much a spossible before casting can't be a bad thing if the cure time allows enough time to do it!
Also on a side note, I've read a few times that people suggested to dab or pour silicone in small detailed area first when mold making,
but from my experience and the tutorials I've seen its usually recommended to just pour from one corner (so only on one spot don't move) and let the silicone work its way on its own,
as moving around (and 'overlapping' pours) might lead to more bubbles getting trapped.
So depending on which way you prefer this might be something to try as well as I never had issues with bubbles trapped in silicone molds!
Not sure if this can be applied to the resin casting step somehow tho since you pour thru a channel inside a at least two part mold.