If you type with "proper" form, then the variable will feel very natural...If you type with 2-3 fingers on each hand, it'll feel weird I'm sure.
For longer typing sessions, it is significantly easier on my hands..and it is always very noticeable (for me) when I switch to a uniform Topre or Cherry that my pinky fingers are getting a bit tired...
I think the only problem I had with it was I had to get used to how I rest my fingers on home row as I'd get tons of accidental aaaaaaaaaaaaa...not an issue any longer but used to be...
I also think variable sucks for gaming....But outside of that, while I probably enjoy typing on my HHKB more, variable RF is probably my main, it is just easier on my hands...