Hopefully you'll sell enough Tactile Pro 4 keyboards to be able to afford a code signing certificate ;-)
What do you mean by hold option? I don't have an option key. The three keys along the bottom row are ctrl, Windows and alt. None of those are spare, unlike ctrl on the Mac which, unless something radical has changed since Tiger, does nothing on a Mac outside of Terminal.
What you meant was, the "driver" removes almost the entirety of what the Windows key exists for (you even got a list of these with the Dell AT10* series keyboards, but there are far more shortcuts now than in 1995). No more Win+E (Explorer), Win+R (Run), Win+L (lock), Win+P (projector control), Win+U ("Fore–ground win–dow …"), Win+B (focus the system tray) and the rest of the new ones added in Windows 7. I don't know if it also kills off Win+Arrows (restore or minimise window, maximise window, position window to left or right side of the desktop) in Windows 7, probably not as they're not alphanumeric; I can't test that from home.
The Windows key is also ripe for custom bindings to unused shortcuts such as Win+V (paste special for programs that that don't have it), Win+J (launch JujuEdit), Win+X (paste makeshift GUID, long story). It is however not a spare key.
There's no global solution. In the UK the alt gr key is vestigial and therefore spare (it only provides access to ¦, €, and acute accents), although I find it hard to press so I use ctrl+alt instead, which officially simulates it (they're not equivalent – AutoHotkey bindings can cause horrible key jamming as a result, but I forget which way around goes terribly wrong).
I don't think the key jam is anything to do with "USB devices" (

), it's to do with Autohotkey screwing around with event sequences, and any non-standard software
will cause issues. It's mice I have trouble with, but that's because I have cheapo Microsoft IntelliMouse Opticals, and they're trash.