Yeah if you're a snail... I'd be all for trying zowie mice but their DPI doesn't go high enough for me
Are you talking for gaming, general use, or both?
Have you ever seen pro FPS players mice settings? Fatal1ty has his DPI turned way down, it takes really large arm/hand movements but your accuracy is enhanced once you get used to it. After I saw his settings at one Quakecon I dropped my DPI also and was able to actually kill him once.
Now for RTS gaming it may be completely different, but I still like a medium setting so I can get around the screen easily but not overshoot/miss things with too much sensitivity.