It will be VERY difficult and practically impossible to cut a plate with a hand tool. If you have access to a manual mill where you turn wheels, it won't be as hard but it will remain freakishly tedious to the point where the average human would die from boredom before having cut half the holes.
You pretty much need a CNC laser cutter. A CNC waterjet cutter will suffice and a CNC mill is also able to do it but not as easily. I recommend you to draw it digitally, have someone take a look at it and then order it at a shop which cuts things for you.